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Selection of twenty-four highly informative SNP markers for human identification and paternity analysis in Koreans.

Lee HY, Park MJ, Yoo JE, Chung U, Han GR, Shin KJ

Department of Forensic Medicine, College of Medicine, Yonsei University, Seoul 120-752, Republic of Korea.

A number of DNA marker types suitable for human identification and parentage testing have been developed, of which single nucleotide polymorphisms (SNPs) merit attention as they are abundant, genetically stable, and amenable to high-throughput automated analysis. In this regard, 24 highly informative SNP markers representing each 22 autosome and both sex chromosomes were selected, and the allele and genotype frequencies of these SNPs were determined in a group composed of 30 unrelated Koreans. Based on frequency data from this group, the estimated probability of identity (P(I)) and probability of paternity exclusion (P(E)) with 22 autosomal SNP loci were 1.905x10(-10) and 98.9%, respectively. The SNPs in this study offer a small but highly accurate database that will be an essential reference for SNP-based forensic application in the future.

Published 10 January 2005 in Forensic Sci Int, 148(2): 107-12.
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